| Autor: |
Mohammad Movahedi, Angela Cesta, Claire Bombardier, Edward C Keystone, Denis Choquette, Xiuying Li, Louis Coupal, OBRI Investigators |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
BMJ Open, Vol 13, Iss 3 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2044-6055 |
| DOI: |
10.1136/bmjopen-2022-063198 |
| Popis: |
Objectives The similarity in retention of tumour necrosis factor inhibitors (TNFi) and tofacitinib (TOFA) was previously reported separately by the Ontario Best Practices Research Initiative and the Quebec cohort Rhumadata. However, because of small sample sizes in each registry, we aimed to confirm the findings by repeating the analysis of discontinuation of TNFi compared with TOFA, using pooled data from both these registries.Design Retrospective cohort study.Setting Pooled data from two rheumatoid arthritis (RA) registries in Canada.Participants Patients with RA starting TOFA or TNFi between June 2014 and December 2019 were included. A total of 1318 patients were included TNFi (n=825) or TOFA (n=493).Outcome measures Time to discontinuation was assessed using Kaplan-Meier survival and Cox proportional hazards regression analysis. Propensity score (PS) stratification (deciles) and PS weighting were used to estimate treatment effects.Results The mean disease duration in the TNFi group was shorter (8.9 years vs 13 years, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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