| Autor: |
Amira Mohamed Noureldin Abdelrahman, Safia Mohammed Diab, Howyda Moh. Kamal Shabaan, Mai Nasser Abdelmomen Ahmed, Reem Nabil |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Egyptian Journal of Medical Human Genetics, Vol 24, Iss 1, Pp 1-11 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2090-2441 |
| DOI: |
10.1186/s43042-023-00423-z |
| Popis: |
Abstract Background The hematopoietic malignancy acute myeloid leukemia is a fatal disease with poor clinical prognoses. Long non-coding RNA taurine-upregulated gene1 (lncRNA TUG1) and zinc finger E-box binding homeobox 2 antisense RNA1 (lncRNA ZEB2-AS1) are reported to participate in the development and progression of different types of malignancies. The goal of the current study was to evaluate the prognostic value of the lncRNAs TUG1 and ZEB2-AS1 as well as their various expression patterns in newly diagnosed Egyptian adult acute myeloid leukemia patients. Methods We assessed the expression levels of both lncRNA TUG1 and lncRNA ZEB2-AS1 using the quantitative real-time reverse transcription polymerase chain reaction technique (qRT-PCR) in 80 newly diagnosed AML patients and 20 healthy subjects. Results lncRNA TUG1 expression was significantly higher in the AML cases compared to the controls (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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