Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis

Autor: Nutan Chaudhari, Alison D. Findlay, Andrew W. Stevenson, Tristan D. Clemons, Yimin Yao, Amar Joshi, Sepidar Sayar, Gordon Wallace, Suzanne Rea, Priyanka Toshniwal, Zhenjun Deng, Philip E. Melton, Nicole Hortin, K. Swaminathan Iyer, Wolfgang Jarolimek, Fiona M. Wood, Mark W. Fear
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-33148-5
Popis: Scars are a significant problem caused by excess collagen in the skin. Here the authors develop a topical drug that reduces collagen stability and leads to improved scar appearance and stiffness in preclinical models.
Databáze: Directory of Open Access Journals
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