The association between vitamin D level and diabetic peripheral neuropathy in patients with type 2 diabetes mellitus: An update systematic review and meta-analysis

Autor: Guang-Bo Qu, Ling-Ling Wang, Xue Tang, Wei Wu, Ye-Huan Sun
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Journal of Clinical & Translational Endocrinology, Vol 9, Iss , Pp 25-31 (2017)
Druh dokumentu: article
ISSN: 2214-6237
DOI: 10.1016/j.jcte.2017.04.001
Popis: Aim: Recently, increasing studies have been carried out to explore the association between vitamin D level and the development of diabetic peripheral neuropathy (DPN) in patients with diabetes mellitus (DM). However, because of the shortcoming in study design and sample size, there is still no clear conclusion. We performed this meta-analysis to examine the exact impact of vitamin D deficiency on DPN in type 2 diabetic patients. Methods: Various databases were searched to identify the potential articles which explored the association between vitamin D level and diabetic peripheral neuropathy in type 2 diabetes. We pooled OR to assess the correlation between vitamin D deficiency and DPN using the random-effects model. The standardized mean difference (SMD) with 95% CI of vitamin D was also calculated to evaluate the vitamin D level between DPN and non DPN in T2DM. Results: There was obvious heterogeneity in those included ten studies (I2 = 94.1%, Cochran Q test P
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