A survey of the adaptive immune genes of the polka-dot batfish Ogcocephalus cubifrons

Autor: Jeremy B. Swann, Christiane Grammer, Michael Schorpp, Thomas Boehm
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: BMC Immunology, Vol 24, Iss 1, Pp 1-12 (2023)
Druh dokumentu: article
ISSN: 1471-2172
DOI: 10.1186/s12865-023-00557-0
Popis: Abstract Background The anglerfish, belonging to the teleost order Lophiiformes, are a diverse and species-rich group of fish that are known to exhibit a number of unique morphological, reproductive and immunological adaptations. Work to date has identified the loss of specific adaptive immune components in two of the five Lophiiformes sub-orders (Lophioidei and Ceratioidei), while no anomalies have been identified to date in two other sub-orders, Antennaroidei and Chaunacoidei. The immunogenome of the fifth sub-order, Ogcocephaloidei has not yet been investigated, and we have therefore used whole genome shotgun sequencing, combined with RNA-seq, to survey the adaptive immune capabilities of the polka-dot batfish, O. cubifrons, as a representative of this as yet unexplored sub-order. Results We find that the O. cubifrons genome encodes the core genes needed to mount adaptive T and B cell responses. These genes include those necessary for rearranging and editing antigen receptors, the antigen receptors themselves; as well as the co-receptors, signalling molecules, and antigen presenting molecules (both class I and class II) needed for B cell and T cell development and activation. Conclusions From an immune perspective, the polka-dot batfish has a canonical complement of adaptive immune genes, and does not exhibit any of the adaptive immune changes previously identified in monkfish and oceanic anglerfish.
Databáze: Directory of Open Access Journals
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