Cross-species transmission of a novel adenovirus associated with a fulminant pneumonia outbreak in a new world monkey colony.
| Autor: | Eunice C Chen, Shigeo Yagi, Kristi R Kelly, Sally P Mendoza, Ross P Tarara, Don R Canfield, Nicole Maninger, Ann Rosenthal, Abigail Spinner, Karen L Bales, David P Schnurr, Nicholas W Lerche, Charles Y Chiu |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | PLoS Pathogens, Vol 7, Iss 7, p e1002155 (2011) |
| Druh dokumentu: | article |
| ISSN: | 1553-7366 1553-7374 |
| DOI: | 10.1371/journal.ppat.1002155 |
| Popis: | Adenoviruses are DNA viruses that naturally infect many vertebrates, including humans and monkeys, and cause a wide range of clinical illnesses in humans. Infection from individual strains has conventionally been thought to be species-specific. Here we applied the Virochip, a pan-viral microarray, to identify a novel adenovirus (TMAdV, titi monkey adenovirus) as the cause of a deadly outbreak in a closed colony of New World monkeys (titi monkeys; Callicebus cupreus) at the California National Primate Research Center (CNPRC). Among 65 titi monkeys housed in a building, 23 (34%) developed upper respiratory symptoms that progressed to fulminant pneumonia and hepatitis, and 19 of 23 monkeys, or 83% of those infected, died or were humanely euthanized. Whole-genome sequencing of TMAdV revealed that this adenovirus is a new species and highly divergent, sharing |
| Databáze: | Directory of Open Access Journals |
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