| Autor: |
Mélissande Louis, Ali Tahrioui, Julien Verdon, Audrey David, Sophie Rodrigues, Magalie Barreau, Maëliss Manac’h, Audrey Thiroux, Baptiste Luton, Charly Dupont, Marie Le Calvé, Alexis Bazire, Alexandre Crépin, Maximilien Clabaut, Emilie Portier, Laure Taupin, Florian Defontaine, Thomas Clamens, Emeline Bouffartigues, Pierre Cornelis, Marc Feuilloley, Jocelyne Caillon, Alain Dufour, Jean-Marc Berjeaud, Olivier Lesouhaitier, Sylvie Chevalier |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Microorganisms, Vol 10, Iss 9, p 1788 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2076-2607 |
| DOI: |
10.3390/microorganisms10091788 |
| Popis: |
Phthalates are used in a variety of applications—for example, as plasticizers in polyvinylchloride products to improve their flexibility—and can be easily released into the environment. In addition to being major persistent organic environmental pollutants, some phthalates are responsible for the carcinogenicity, teratogenicity, and endocrine disruption that are notably affecting steroidogenesis in mammals. Numerous studies have thus focused on deciphering their effects on mammals and eukaryotic cells. While multicellular organisms such as humans are known to display various microbiota, including all of the microorganisms that may be commensal, symbiotic, or pathogenic, few studies have aimed at investigating the relationships between phthalates and bacteria, notably regarding their effects on opportunistic pathogens and the severity of the associated pathologies. Herein, the effects of phthalates and their substitutes were investigated on the human pathogen, Pseudomonas aeruginosa, in terms of physiology, virulence, susceptibility to antibiotics, and ability to form biofilms. We show in particular that most of these compounds increased biofilm formation, while some of them enhanced the bacterial membrane fluidity and altered the bacterial morphology. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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