Efficient Synthesis of Isoquinoline Derivatives through Sequential Cyclization–Deoxygenation Reaction of 2-Alkynylbenzaldoximes

Autor: Mojtaba Ayoubi, Ali Nikbakht, Kamran Amiri, Alireza Abbasi Kejani, Hossein Zahedian Tejeneki, Saeed Balalaie
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: SynOpen, Vol 06, Iss 01, Pp 11-15 (2022)
Druh dokumentu: article
ISSN: 2509-9396
DOI: 10.1055/s-0040-1719870
Popis: We describe a novel, simple, robust, and efficient cyclization/deoxygenation approach for the synthesis of functionalized isoquinoline derivatives. Over the course of continued studies on o-alkynylbenzaldoxime cyclization reactions, the formation of cyclic nitrones through 6-endo-dig cyclization was achieved using silver triflate or bromine as an electrophile, and subsequently, the deoxygenation process was carried out in the presence of CS2 in good to high yields.
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