Adverse body composition and lipid parameters in patients with prolactinoma: a case-control study

Autor:	Anna Sophia Posawetz, Christian Trummer, Marlene Pandis, Felix Aberer, Thomas R. Pieber, Barbara Obermayer-Pietsch, Stefan Pilz, Verena Theiler-Schwetz
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Hyperprolactinaemia lipid metabolism total cholesterol LDL cholesterol fat mass prolactin Diseases of the endocrine glands. Clinical endocrinology RC648-665
Zdroj:	BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-9 (2021)
Druh dokumentu:	article
ISSN:	1472-6823
DOI:	10.1186/s12902-021-00733-6
Popis:	Abstract Background Hyperprolactinaemia might cause adverse metabolic effects. The aim of our study was to compare parameters of body composition, glucose and lipid metabolism between untreated patients with prolactinoma and controls and to assess changes after initiation of cabergoline. Methods Case-control study with a retrospectively analyzed follow-up in patients with prolactinoma after initiation of cabergoline therapy. Results 21 patients with prolactinoma (9 micro- and 12 macroprolactinomas; 7 females) and 30 controls were analyzed. Patients with prolactinoma had significantly higher BMI than controls; fat mass did not differ between groups. Only men - but not women - with prolactinoma had significantly higher fat mass at all six sites measured compared to controls. Levels of LDL (130 (107–147.5) vs. 94.5 (80–127.5) mg/dl, p
Databáze:	Directory of Open Access Journals
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