Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier

Autor:	Yelixza I. Avila, Morgan Chandler, Edward Cedrone, Hannah S. Newton, Melina Richardson, Jie Xu, Jeffrey D. Clogston, Neill J. Liptrott, Kirill A. Afonin, Marina A. Dobrovolskaia
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	nucleic acid nanoparticles NANPs cytokines vaccines immunotherapies immunology Organic chemistry QD241-441
Zdroj:	Molecules, Vol 26, Iss 3, p 652 (2021)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules26030652
Popis:	Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs) have demonstrated that variations in the shape, size, and composition lead to distinct patterns in their immunostimulatory properties. While most of these studies have used a single lipid-based carrier to allow for NANPs’ intracellular delivery, it is now apparent that the platform for delivery, which has historically been a hurdle for therapeutic nucleic acids, is an additional means to tailoring NANP immunorecognition. Here, the use of dendrimers for the delivery of NANPs is compared to the lipid-based platform and the differences in resulting cytokine induction are presented.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/8f16ade319414daab6b20f4ae0003a4a Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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