Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer

Autor: Chi-Chang Chang, Chia-Chang Hsu, Teng-Hung Yu, Wei-Chin Hung, Shyh-Ming Kuo, Chia-Chi Chen, Cheng-Ching Wu, Fu-Mei Chung, Yau-Jiunn Lee, Ching-Ting Wei
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: World Journal of Surgical Oncology, Vol 21, Iss 1, Pp 1-10 (2023)
Druh dokumentu: article
ISSN: 1477-7819
DOI: 10.1186/s12957-023-02944-8
Popis: Abstract Background Liver-type fatty acid-binding protein (L-FABP) is widely expressed in hepatocytes and plays a role in lipid metabolism. It has been demonstrated to be overexpressed in different types of cancer; however, few studies have investigated the association between L-FABP and breast cancer. The aim of this study was to assess the association between plasma concentrations of L-FABP in breast cancer patients and the expression of L-FABP in breast cancer tissue. Method A total of 196 patients with breast cancer and 57 age-matched control subjects were studied. Plasma L-FABP concentrations were measured using ELISA in both groups. The expression of L-FABP in breast cancer tissue was examined using immunohistochemistry. Result The patients had higher plasma L-FABP levels than the controls (7.6 ng/mL (interquartile range 5.2–12.1) vs. 6.3 ng/mL (interquartile range 5.3–8.5), p = 0.008). Multiple logistic regression analysis showed an independent association between L-FABP and breast cancer, even after adjusting for known biomarkers. Moreover, the rates of pathologic stage T2+T3+T4, clinical stage III, positive HER-2 receptor status, and negative estrogen receptor status were significantly higher in the patients with an L-FABP level greater than the median. Furthermore, the L-FABP level gradually increased with the increasing stage. In addition, L-FABP was detected in the cytoplasm, nuclear, or both cytoplasm and nuclear of all breast cancer tissue examined, not in the normal tissue. Conclusions Plasma L-FABP levels were significantly higher in the patients with breast cancer than in the controls. In addition, L-FABP was expressed in breast cancer tissue, which suggests that L-FABP may be involved in the pathogenesis of breast cancer.
Databáze: Directory of Open Access Journals
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