Targeting the JAK2/STAT3 signaling pathway with natural plants and phytochemical ingredients: A novel therapeutic method for combatting cardiovascular diseases

Autor: Bing Guo, Yunfeng Yu, Min Wang, Ronghui Li, Xuan He, Siqin Tang, Qili Liu, Yilin Mao
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Biomedicine & Pharmacotherapy, Vol 172, Iss , Pp 116313- (2024)
Druh dokumentu: article
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2024.116313
Popis: The aim of this article is to introduce the roles and mechanisms of the JAK2/STAT3 pathway in various cardiovascular diseases, such as myocardial fibrosis, cardiac hypertrophy, atherosclerosis, myocardial infarction, and myocardial ischemiareperfusion. In addition, the effects of phytochemical ingredients and different natural plants, mainly traditional Chinese medicines, on the regulation of different cardiovascular diseases via the JAK2/STAT3 pathway are discussed. Surprisingly, the JAK2 pathway has dual roles in different cardiovascular diseases. Future research should focus on the dual regulatory effects of different phytochemical ingredients and natural plants on JAK2 to pave the way for their use in clinical trials.
Databáze: Directory of Open Access Journals
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