Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography

Autor: Aritz Juarros, Deitze Otaduy, Josu Martinez-Perdiguero, Aritz Retolaza, Santos Merino
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Sensors, Vol 13, Iss 10, Pp 13960-13968 (2013)
Druh dokumentu: article
ISSN: 1424-8220
DOI: 10.3390/s131013960
Popis: In this work we present a surface plasmon resonance sensor based on enhanced optical transmission through sub-wavelength nanohole arrays. This technique is extremely sensitive to changes in the refractive index of the surrounding medium which result in a modulation of the transmitted light. The periodic gold nanohole array sensors were fabricated by high-throughput thermal nanoimprint lithography. Square periodic arrays with sub-wavelength hole diameters were obtained and characterized. Using solutions with known refractive index, the array sensitivities were obtained. Finally, protein absorption was monitored in real-time demonstrating the label-free biosensing capabilities of the fabricated devices.
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