| Autor: |
Ke-ren LONG, Xiao-kai LI, Ruo-wei ZHANG, Yi-ren GU, Min-jie DU, Xiang-yang XING, Jia-xiang DU, Miao-miao MAI, Jing WANG, Long JIN, Qian-zi TANG, Si-lu HU, Ji-deng MA, Xun WANG, Deng-ke PAN, Ming-zhou LI |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of Integrative Agriculture, Vol 21, Iss 9, Pp 2675-2690 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2095-3119 |
| DOI: |
10.1016/j.jia.2022.07.014 |
| Popis: |
Follistatin (FST) is an important regulator of skeletal muscle growth and adipose deposition through its ability to bind to several members of the transforming growth factor-β (TGF-β) superfamily, and thus may be a good candidate for future animal breeding programs. However, the molecular mechanisms underlying the phenotypic changes have yet to be clarified in pig. We generated transgenic (TG) pigs that express human FST specifically in skeletal muscle tissues and characterized the phenotypic changes compared with the same tissues in wild-type pigs. The TG pigs showed increased skeletal muscle growth, decreased adipose deposition, and improved metabolism status (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect