Acute lymphoblastic leukemia: primary bone manifestation with hypercalcemia in a child

Autor:	Cristiano C. Oliveira, Luan Kucko, Eric J. Hirama, Helena M. Guerra, Simone A. Terra, Lied M. Santiago, Manuella P. Segredo, Ligia Niero-Melo, Maria Aparecida C. Domingues
Jazyk:	angličtina
Předmět:	precursor b-cell lymphoblastic leukemia-lymphoma bone marrow hypercalcemia Pathology RB1-214
Zdroj:	Jornal Brasileiro de Patologia e Medicina Laboratorial, Vol 53, Iss 1, Pp 61-64
Druh dokumentu:	article
ISSN:	1676-2444 1678-4774
DOI:	10.5935/1676-2444.20170010
Popis:	ABSTRACT Primary bone manifestation associated with hypercalcemia is an infrequent presentation of acute lymphoblastic leukemia (ALL) in children. An 8-year-old girl was admitted with bone and abdomen pain, vomiting, fever, headache, anemia, elevated serum calcium and normal parathyroid hormone levels. Bone radiographs: osteolytic lesions. Bone marrow biopsy showed an infiltration by ALL with immunohistochemical positivity for CD45, CD20, CD79a, TdT and CD10, clinically characterized by hypercalcemia, multifocal osteolytic lesions and single cytopenia. Bone marrow biopsy was a relevant aid in establishing the diagnosis of multifocal osteolytic lesions, associated with hypercalcemia.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/8ee8d675fdac420d8c18a66042a7b7e0 Zobrazit plný text záznamu View record in DOAJ