The efficacy of topological properties of functional brain networks in identifying major depressive disorder

Autor:	Kejie Xu, Dan Long, Mengda Zhang, Yifan Wang
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Major depressive disorder rs-fMRI Functional connectivity network Topological properties Identification Medicine Science
Zdroj:	Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Druh dokumentu:	article
ISSN:	2045-2322
DOI:	10.1038/s41598-024-80294-5
Popis:	Abstract Major Depressive Disorder (MDD) is a common mental disorder characterized by cognitive impairment, and its pathophysiology remains to be explored. In this study, we aimed to explore the efficacy of brain network topological properties (TPs) in identifying MDD patients, revealing variational brain regions with efficient TPs. Functional connectivity (FC) networks were constructed from resting-state functional magnetic resonance imaging (rs-fMRI). Small-worldness did not exhibit significant variations in MDD patients. Subsequently, two-sample t-tests were employed to screen FC and reconstruct the network. The discriminative ability of TPs between MDD patients and healthy controls was analyzed using receiver operating characteristic (ROC), ROC analysis showed the small-worldness of binary reconstructed FC network (p
Databáze:	Directory of Open Access Journals
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