EXPERIMENTAL STUDIES OF THE SPECIFICITY OF IMMUNE RESPONSE IN VARIOUS OCCUPATIONAL DISEASES
| Autor: | D. V. Fomenko, N. N. Mikhailova, A. S. Kazitskya, E. V. Ulanova, Y. A. Prokopyev |
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| Jazyk: | ruština |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Acta Biomedica Scientifica, Vol 0, Iss 5(2), Pp 115-119 (2012) |
| Druh dokumentu: | article |
| ISSN: | 2541-9420 2587-9596 |
| Popis: | Experimental models of anthracosilicosis (AS) and fluoride intoxication. (FI) show that the inhalation of coal and. rock dust (CRD) results in an early anti-inflammatory cytokine response (IL-4, IL-10) and. activation of humoral immunity on the background of lower level of proinflammatory cytokines. Later stages of the CRD activity are characterized by inflammation and. immunodeficiency. FI start is accompanied, by an increase of proinflammatory cytokines (IL-8, TNF-α). Anti-inflammatory protection is seen on the later stages (IL-10), immunoglobulin levels did. not change during 6 weeks of FI. Recommendations for the prevention of the anthracosilicosis and. fluoride intoxication given. |
| Databáze: | Directory of Open Access Journals |
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