Bioequivalence study of ondansetron tablets by HPLC-MS
| Autor: | E. S. Stepanova, M. V. Ovcharov, S. S. Barsegyan, S. M. Nikonova, V. V. Shilov, V. V. Chistyakov |
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| Jazyk: | ruština |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 21-26 (2014) |
| Druh dokumentu: | article |
| ISSN: | 2587-7836 2686-8830 |
| Popis: | Within the cross, a single, open, randomized study with a week washout period, the two sequences has been studied bioequivalence of tablet forms two ondansetron 18 volunteers (8 mg dosage). Plasma samples were analyzed by a validated HPLC-MS, tropisetron was used as the internal standard. Limit of quantification was 1 ng/ml. Analyzed for drugs following pharmacokinetic parameters were calculated: AUC0-t, Cmax, Tmax, MRT, Cmax/AUC ' 90% confidence interval for log-transformed values of AUC0-t was 0,9507 - 1,0037, of AUC(0-∞ ). was 0,9402-0,9974, of C was 0,9255 - 1,0095. The study concluded that bioequivalence compared ondansetron drugs. |
| Databáze: | Directory of Open Access Journals |
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