Hepatic non-parenchymal S100A9-TLR4-mTORC1 axis normalizes diabetic ketogenesis

Autor: Gloria Ursino, Giorgio Ramadori, Anna Höfler, Soline Odouard, Pryscila D. S. Teixeira, Florian Visentin, Christelle Veyrat-Durebex, Giulia Lucibello, Raquel Firnkes, Serena Ricci, Claudia R. Vianna, Lin Jia, Mirjam Dirlewanger, Philippe Klee, Joel K. Elmquist, Johannes Roth, Thomas Vogl, Valérie M. Schwitzgebel, François R. Jornayvaz, Andreas Boland, Roberto Coppari
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-31803-5
Popis: Excess ketogenesis can lead to ketoacidosis, a serious complication in patients with diabetes. Here the authors report an insulin independent pathway, the hepatic nonparenchymal S100A9-TLR4-mTORC1 axis, that is able to normalize diabetic ketogenesis and pre-clinical data to suggest potential for development of S100A9 based adjunctive therapy to insulin.
Databáze: Directory of Open Access Journals