Localization patterns of cathepsins K and X and their predictive value in glioblastoma

Autor: Breznik Barbara, Limback Clara, Porcnik Andrej, Blejec Andrej, Krajnc Miha Koprivnikar, Bosnjak Roman, Kos Janko, Van Noorden Cornelis J.F., Lah Tamara T.
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Radiology and Oncology, Vol 52, Iss 4, Pp 433-442 (2018)
Druh dokumentu: article
ISSN: 1581-3207
DOI: 10.2478/raon-2018-0040
Popis: Glioblastoma is a highly aggressive central nervous system neoplasm characterized by extensive infiltration of malignant cells into brain parenchyma, thus preventing complete tumor eradication. Cysteine cathepsins B, S, L and K are involved in cancer progression and are overexpressed in glioblastoma. We report here for the first time that cathepsin X mRNA and protein are also abundantly present in malignant glioma.
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