Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI

Autor: Takahiro Mori, Rui Zhai, Richiro Ushimaru, Yudai Matsuda, Ikuro Abe
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-24685-6
Popis: Many endoperoxide-containing natural products have been isolated, but the biosynthesis of the endoperoxides remains unclear. Here, the authors report the structural and functional analysis of the NvfI endoperoxidase that catalyzes the formation of fumigatonoid A in the biosynthesis of novofumigatonin, and show that it does not employ tyrosyl radical in the reaction.
Databáze: Directory of Open Access Journals