Systemic Administration and Targeted Delivery of Immunogenic Oncolytic Adenovirus Encapsulated in Extracellular Vesicles for Cancer Therapies

Autor:	Mariangela Garofalo, Alessandro Villa, Nicoletta Rizzi, Lukasz Kuryk, Vincenzo Mazzaferro, Paolo Ciana
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Oncolytic adenovirus extracellular vesicles lung cancer immunocompetent mouse model in vivo imaging Microbiology QR1-502
Zdroj:	Viruses, Vol 10, Iss 10, p 558 (2018)
Druh dokumentu:	article
ISSN:	1999-4915
DOI:	10.3390/v10100558
Popis:	Oncolytic viruses (OV) are engineered to infect, replicate in and kill cancer cells. Currently, the OV therapeutic approach is mainly restricted to neoplasia amenable to direct local administration of viral particles, while the possibility of a systemic delivery of cancer-tropic viruses would extend the OV application to the treatment of metastatic neoplasia. Herein, we applied in vivo/ex vivo imaging to demonstrate that cancer tropism is achieved when OV are encapsulated inside extracellular vesicles (EV) administered intravenously (i.v.), but not when injected intraperitoneally (i.p.). Moreover, we show that the therapeutic procedure adopted does not alter the immunomodulatory properties of the viruses.
Databáze:	Directory of Open Access Journals
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