Differential response to intravitreal dexamethasone implant in naïve and previously treated diabetic macular edema eyes

Autor: Javier Zarranz-Ventura, Barbara Romero-Núñez, Carolina Bernal-Morales, Daniel Velazquez-Villoria, Anna Sala-Puigdollers, Marc Figueras-Roca, Sergio Copete, Laura Distefano, Anna Boixadera, Jose García-Arumi, Alfredo Adan, on behalf of the Hospital Clínic - Hospital Vall de Hebron Intravitreal Dexamethasone Implant study group
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: BMC Ophthalmology, Vol 20, Iss 1, Pp 1-12 (2020)
Druh dokumentu: article
ISSN: 1471-2415
DOI: 10.1186/s12886-020-01716-2
Popis: Abstract Background To identify different response patterns to intravitreal dexamethasone implants (IDI) in naïve and previously treated (PT) diabetic macular edema (DME) eyes in a real-life setting. Methods 342 IDI injections (203 DME eyes) were included. Number of IDI injections, percentage (%) of eyes with 1, 2, 3 and ≥ 4 injections, time to reinjections, visual acuity (VA), intraocular pressure (IOP) and central retinal thickness (CRT) were evaluated for naïve and PT DME eyes over 24 months. Results Mean number of injections was significantly lower in naïve vs PT DME eyes (1.40 ± 0.9 vs 1.82 ± 0.9, p
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