HPMC-based fast-dissolving oral films with galantamine-loaded chitosan nanoparticles

Autor: Dilyana Georgieva, Bistra Kostova
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Pharmacia, Vol 71, Iss , Pp 1-6 (2024)
Druh dokumentu: article
ISSN: 2603-557X
DOI: 10.3897/pharmacia.71.e134376
Popis: Alzheimer’s disease is a brain disorder characterized by a gradual decline in memory, thinking, behavior, and social skills. Galantamine hydrobromide is a reversible competitive cholinesterase inhibitor used for managing Alzheimer’s disease. Its oral administration, however, is accompanied by unwanted side effects, such as gastrointestinal disturbances, nausea, and vomiting. These side effects could be avoided by the incorporation of galantamine into nanoparticles. The present study describes the preparation and characterization of HPMC-based fast-dissolving oral films with galantamine-loaded chitosan nanoparticles. Galantamine-loaded chitosan nanoparticles were prepared using the ionotropic gelation method. High values for loading efficiency were established. DLS was used to evaluate the particle size and the Z-potential. The polymer used in this study for the preparation of the fast-dissolving oral films was HPMC, and PEG 400 was used as a plasticizer. The quality of the prepared films was evaluated based on the following criteria: flexibility, spreading ability, adhesiveness, non-sticky and easily peeled, and appearance. The thickness, folding endurance, and disintegration times of the prepared films were determined. In vitro dissolution studies were conducted in order to establish the drug release rate from the films.
Databáze: Directory of Open Access Journals