GC–MS analysis and green synthesis of silver nanoparticles using Emblica officinalis leaves and evaluation of its antioxidant and in-vitro anti-hypercholesterolemic potential

Autor: Nadeem Ahmad Siddique, Ali Mohammed Mohammed Ali AL-Samman, Kahkashan
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Taibah University for Science, Vol 18, Iss 1 (2024)
Druh dokumentu: article
ISSN: 16583655
1658-3655
DOI: 10.1080/16583655.2024.2390211
Popis: Currently, various heart conditions, such as hyperlipidaemia, are causing fear among people worldwide. In this research, silver nanoparticles (AgNPs) were produced using Emblica Officinallis leaf extract (EOLE). The synthesis of EOLEAgNPs was examined using UV-visible spectrophotometry at 430 nm, while the shape was determined through SEM analysis. The EDX detected a clear peak of silver (Ag) at 3.4 keV, whereas XRD exhibited a peak distribution at 2 θ° values. The TEM demonstrated a protective layer (100 nm) surrounding EOLEAgNPs. The FTIR (400-4000 cm−1) suggests the phyto-compounds that caused the reduction of AgNO3 to Ag0 ions. The EOLEAgNPs showed a lower value (IC50 = 0.12) and greater antioxidant effects compared to EOLE (IC50 = 4.9). In fact, we discovered that the HMG-CoA reductase enzyme activity of EOLEAgNPs (75.38 ± 0.06) was greater than that of EOLE (37.36 ± 0.03). E. officinallis have a high level of polyphenolics as detected by GCMS-MS. Our research results in the inhibition of HMG-CoA reductase enzyme by EOLEAgNPs, which can effectively treat hyperlipidaemia and promote the development of lipid-lowering biomedicines.
Databáze: Directory of Open Access Journals
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