Antimicrobial and Anti-Oxidative Activities of 12-Arylbenzoacridines
| Autor: | Boonsong Wungsintaweekul, Kayoko Abe, Rintaro Koga, Yoshinori Katakura, Kohei Torikai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Indonesian Journal of Chemistry, Vol 20, Iss 5, Pp 1199-1205 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1411-9420 2460-1578 |
| DOI: | 10.22146/ijc.53411 |
| Popis: | Searching biologically active compounds has been one of the major duties of organic chemists. We previously constructed a library of synthetic 12-arylbenzoacridines and found estrogenic and anti-estrogenic agents. With taking the shot-gun approach into consideration, further exploration for bioactive species in the above library was carried out. As a result, new antibacterial agents against S. aureus (MIC = 16 μM), E. coli (MIC = 7.8 μM), E. faecalis (MIC = 0.98 μM), and A. baumannii (MIC = 31 μM) were found. Moreover, we also unveiled that some of the tested compounds exhibit cell-based anti-oxidative activity. These results clearly show a good potential of 12-arylbenzoacridines as novel pharmacophores, which is useful to establish various medicines. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|