New approach toward the synthesis of deuterated pyrazolo[1,5-a]pyridines and 1,2,4-triazolo[1,5-a]pyridines
| Autor: | Aleksey Yu. Vorob’ev, Vyacheslav I. Supranovich, Gennady I. Borodkin, Vyacheslav G. Shubin |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 800-805 (2017) |
| Druh dokumentu: | article |
| ISSN: | 1860-5397 |
| DOI: | 10.3762/bjoc.13.80 |
| Popis: | An efficient and operationally simple synthesis of 7-deuteropyrazolo[1,5-a]pyridine and 7-deutero-1,2,4-triazolo[1,5-a]pyridine derivatives using α-H/D exchange of 1-aminopyridinium cations in basic D2O followed by a 1,3-cycloaddition of acetylenes and nitriles is presented. A high regioselectivity and a high degree of deuterium incorporation were achieved. The procedure was applied for several 4-R-1-aminopyridinium cations (R = H, Me, OMe). |
| Databáze: | Directory of Open Access Journals |
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