| Autor: |
Maria Simone Oliveira Lima, Benedito Borges da Silva, Menandro Lima de Medeiros, Alesse Ribeiro dos Santos, Emerson Davi do Nascimento Brazil, Walberto Monteiro Neiva Eulálio Filho, Jerusia Oliveira Ibiapina, Antônio Gilberto Albuquerque Brito, Pedro Vitor Lopes Costa |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Reproductive Biology and Endocrinology, Vol 19, Iss 1, Pp 1-6 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1477-7827 |
| DOI: |
10.1186/s12958-021-00752-x |
| Popis: |
Abstract Background Uterine myomas are the most frequent benign solid pelvic tumors in women of reproductive age. At present, uterine myomas are the most common indication for hysterectomy because of the morbidity they cause, including intense bleeding, compression of adjacent organs, pain, and infertility. Some studies show that vitamin D receptor (VDR) expression is correlated with the etiology of uterine leiomyomas. This study aimed to assess the expression of VDR in uterine leiomyoma and nonneoplastic myometrial tissue. Methods A controlled cross-sectional study involving 40 women who underwent abdominal hysterectomy the Department of Gynecology of the Getúlio Vargas Hospital of Federal University of Piauí, Brazil, was performed to compare the immunohistochemical expression of VDR in samples of uterine leiomyoma tissue with adjacent nonneoplastic myometrial tissue. The mean percetages of stained nuclei in the two groups was compared by Student’s t teste, with significance established at p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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