The Suppressive Activity of Water Mimosa Extract on Human Gastric Cancer Cells

Autor: Thanh Quang Nguyen, Hoang Nhat Minh Nguyen, Dai-Hung Ngo, Phuoc-Hien Phan, Thanh Sang Vo
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Applied Sciences, Vol 12, Iss 13, p 6817 (2022)
Druh dokumentu: article
ISSN: 2076-3417
DOI: 10.3390/app12136817
Popis: Epidemiological studies have evidenced that natural dietary products can prevent or manage gastric cancer. Neptunia oleracea, an aquatic vegetable and edible plant, has been reported to have anti-cancer properties. In this study, N. oleracea extract’s suppression of gastric cancer cells was investigated on an in vitro experimental model. We found that ethyl acetate (EtOAc) extract inhibited cell proliferation at IC50 value of 172 µg/mL. Moreover, the treatment of EtOAc extract at a concentration of 50 µg/mL for 24 h caused suppression of cancer cell migration. Notably, a real-time PCR assay revealed that EtOAc extract induced the process of apoptosis via upregulating the mRNA expression level of caspase-8, Bax, caspase-9, and caspase-3 in cancer cells. In conclusion, N. oleracea had potential anti-cancer activity against gastric cancer cells, suggesting its role in the prevention and management of gastric cancer.
Databáze: Directory of Open Access Journals