| Autor: |
Xinying Fang, Xinyi Liu, Vernon M. Chinchilli, Michael Wang, Hong-Gang Wang, Nikolay V. Dokholyan, Chan Shen, J. Jack Lee, Shouhao Zhou |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Journal of Clinical and Translational Science, Vol 7 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2059-8661 |
| DOI: |
10.1017/cts.2023.642 |
| Popis: |
REAP-2 is an interactive dose-response curve estimation tool for Robust and Efficient Assessment of drug Potency. It provides user-friendly dose-response curve estimation for in vitro studies and conducts statistical testing for model comparisons with a redesigned user interface. We also make a major update of the underlying estimation method with penalized beta regression, which demonstrates great reliability and accuracy in dose estimation and uncertainty quantification. In this note, we describe the method and implementation of REAP-2 with a highlight on potency estimation and drug comparison. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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