Comparison between ImmunoCAP and multiple antigen simultaneous tests for measuring Aspergillus-specific Immunoglobulin E levels in Aspergillus-sensitized patients
| Autor: | Kazunobu Kuwabara, Tatsuyoshi Yokoi, Takazumi Yoshida, Mamoru Shiga, Masahiro Hirose, Rieko Kondo, Kayoko Matsunaga, Masashi Nakamura, Takahiko Horiguchi |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Fujita Medical Journal, Vol 4, Iss 3, Pp 66-69 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2189-7247 2189-7255 |
| DOI: | 10.20407/fmj.4.3_66 |
| Popis: | Objectives: Aspergillus sensitization is important for patients with asthma. In Japan, the methods applied to measure allergen-specific immunoglobulin E (IgE) levels in blood are the single antigen test, ImmunoCAP (IC), and multiple antigen simultaneous tests, View Allergy® (VA) or MAST IV® (MA). Here, we report the concordance rates (CR) for Aspergillus-specific IgE levels between IC and VA or MA. Methods: Aspergillus-specific IgE levels in serum samples from 34 male and 23 female patients with bronchial asthma were measured by ImmunoCAP, View Allergy® (both Thermo Fisher Scientific, Uppsala, Sweden) and MAST IV® (Hitachi Chemical Diagnostics, Inc. Mountain View, CA, USA). Results of Class 1 or greater were regarded as positive, and the CRs between the methods were assessed. Results: Of the 57 patients, 24 were found to be positive for Aspergillus-specific IgE by IC, and 5 had allergic bronchopulmonary aspergillosis (ABPA). Significant intraclass correlations were observed between IC and VA (r=0.964, p |
| Databáze: | Directory of Open Access Journals |
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