Clonal Population of Flucytosine-Resistant Candida tropicalis from Blood Cultures, Paris, France

Autor:	Marie Desnos-Ollivier, Stéphane Bretagne, Claire Bernède, Vincent Robert, Dorothée Raoux, Elisabeth Chachaty, Elisabeth Forget, Claire Lacroix, Françoise Dromer
Jazyk:	angličtina
Rok vydání:	2008
Předmět:	Candida tropicalis candidemia flucytosine antifungal drug resistance polymorphic microsatellite markers multilocus sequence typing Medicine Infectious and parasitic diseases RC109-216
Zdroj:	Emerging Infectious Diseases, Vol 14, Iss 4, Pp 557-565 (2008)
Druh dokumentu:	article
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid1404.071083
Popis:	Candida tropicalis is a diploid ascomycetes yeast responsible for 4%–24% of candidemia. Resistance to flucytosine is rarely described for this species but was observed for 45 (35%) of 130 C. tropicalis isolates recovered from blood cultures in the Paris area in a 4-year survey. The aims of this study were to test the hypothesis that the flucytosine-resistant isolates could represent a subgroup and to determine the relationship between epidemiologic and genomic data. Epidemiologic data and gene sequences were analyzed, and molecular typing was performed. Our results suggest that a clone of flucytosine-resistant isolates, associated with malignancies and a lower mortality than that for other C. tropicalis isolates, is widespread in the Paris area. We propose the analysis of 2 polymorphic microsatellite markers coupled with URA3 sequencing to track the clone.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/aae8e663ae3d44ada2b0a2edf630bd81 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF