| Autor: |
CHEN Kun, ZHANG Jing, HONG Liang, JIA Min, TAO Jing, LIANG Minhong |
| Jazyk: |
čínština |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Shanghai yufang yixue, Vol 34, Iss 9, Pp 854-859 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1004-9231 |
| DOI: |
10.19428/j.cnki.sjpm.2022.21920 |
| Popis: |
ObjectiveTo determine the characteristics of human immunodeficiency virus type 1 （HIV-1） subtypes among newly confirmed HIV-1 patients in Hongkou District of Shanghai， and provide evidence for establishing HIV-1 subtype database and precise prevention and control strategy against AIDS in Hongkou District of Shanghai.MethodsA total of 119 plasma samples from newly confirmed HIV-1 patients in Hongkou District in 2016 were used to detect HIV-1 RNA pol gene by using reverse transcription PCR. HIV-1 subtypes were determined with Los Alamos 2022 HIV-1 gene database using HIV-BLAST tool， and then characterized by epidemiological data.ResultsIn the 119 samples， a total of 89 pol gene fragments were obtained， which were mainly classified as CRF07_BC （38.2%）， CRF01_AE （36.0%）， and subtype B （13.5%）. Furthermore， two new recombinant subtype CRF55_01B and two unique recombinant subtype URF_0107 were identified （2.3%）.ConclusionIn 2016， HIV-1 subtypes in Hongkou District are mainly CRF07_BC and CRF01_AE. In addition， new recombinant subtype CRF55_01B and unique recombinant subtype URF_0107 have appeared in Hongkou District. It warrants a need of enhanced surveillance. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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