Serum Soluble Mediator Profiles and Networks During Acute Infection With Distinct DENV Serotypes

Autor: Mikelly Santos Coutinho-da-Silva, Pedro Henrique Ferreira Sucupira, Kelly Alves Bicalho, Ana Carolina Campi-Azevedo, Joaquim Pedro Brito-de-Sousa, Vanessa Peruhype-Magalhães, Maria Rios, Andréa Teixeira-Carvalho, Jordana Grazziela Alves Coelho-dos-Reis, Lis Ribeiro do Valle Antonelli, Vitor Bortolo de Rezende, Fernanda Ludolf Ribeiro de Melo, Cristiana Couto Garcia, Jesuanne Carla Silva-Andrade, Ismael Artur da Costa-Rocha, Michele de Souza Bastos, Lucia Alves da Rocha, Valderjane Aprigio Silva, Ewerton da Silva Ferreira, Eveny Perlize Melo Marinho, Allyson Guimarães Costa, Matheus de Souza Gomes, Laurence Rodrigues Amaral, Erilene Cristina da Silva Furtado, Eliana Vieira Pinto da Silva, Bruna Alves Ramos, Éder Barros dos Santos, Maria Nazaré Oliveira Freitas, Pedro Fernando da Costa Vasconcelos, Olindo Assis Martins-Filho, Márcio Sobreira Silva Araújo, Milene Silveira Ferreira, Livia Carício Martins
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Frontiers in Immunology, Vol 13 (2022)
Druh dokumentu: article
ISSN: 1664-3224
DOI: 10.3389/fimmu.2022.892990
Popis: A panoramic analysis of chemokines, pro-inflammatory/regulatory cytokines, and growth factors was performed in serum samples from patients with acute DENV infection (n=317) by a high-throughput microbeads array. Most soluble mediators analyzed were increased in DENV patients regardless of the DENV serotype. The substantial increase (≥10-fold) of CXCL10, IL-6, and IFN-γ, and decreased levels of PDGF (
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