Interference of Monoclonal Gammopathy with Fibrinogen Assay Producing Spurious Dysfibrinogenemia

Autor: Francesca Martini, Nadia Cecconi, Aldo Paolicchi, Sara Galimberti, Giulia Cervetti, Gabriele Buda, Mario Petrini
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: TH Open, Vol 03, Iss 01, Pp e64-e66 (2019)
Druh dokumentu: article
ISSN: 2512-9465
DOI: 10.1055/s-0039-1683969
Popis: Abnormal coagulation properties indicative of a dysfibrinogenemia were found in the plasma of an asymptomatic 65-year-old male. An immunoglobulin k light chain was found to interfere with Fg functional assay and coagulation tests (activated partial thromboplastin time, prothrombin time, and thrombin time). Steroid therapy reduced the inhibitory effect (after dexamethasone treatment coagulation test and functional Fg value normalized). Spurious dysfibrinogenemia associated with light chain monoclonal gammopathy of undetermined significance was diagnosed.
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