Laser Photobiomodulation for a Complex Patient with Severe Hydroxyurea-Induced Oral Ulcerations

Autor: Marco Cabras, Adriana Cafaro, Alessio Gambino, Roberto Broccoletti, Ercole Romagnoli, Davide Marina, Paolo G. Arduino
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Case Reports in Dentistry, Vol 2016 (2016)
Druh dokumentu: article
ISSN: 2090-6447
2090-6455
DOI: 10.1155/2016/9810480
Popis: Patients affected by polycythemia vera (PV), a myeloproliferative neoplasm characterized by an elevated red blood cell mass, are at high risk of vascular and thrombotic complications. Conventional therapeutic options aim at reducing vascular and thrombotic risk; low-dose aspirin and phlebotomy are first-line recommendations, for patients at low risk of thrombotic events, whereas cytoreductive therapy, usually hydroxyurea (HU) or interferon alpha, is recommended for high-risk patients. In the present study, we report the case of a patient with persistent oral ulcerations, possibly related to long-lasting HU treatment, firstly treated with topic and systemic corticosteroids and then more effectively with the addition of low-level laser therapy. Laser photobiomodulation has achieved pain control and has contributed to the healing of oral ulcers without any adverse effect; this has permitted a reduction in the dose of systemic corticosteroids and the suspension of the use of the topic ones, due to the long-term stability of oral health, even after the interruption of low-level laser therapy sessions.
Databáze: Directory of Open Access Journals
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