Centrality in the host–pathogen interactome is associated with pathogen fitness during infection

Autor: Núria Crua Asensio, Elisabet Muñoz Giner, Natalia Sánchez de Groot, Marc Torrent Burgas
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Nature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms14092
Popis: Hubs tend to be essential for function in protein networks within organisms. Here, the authors show that during infection, it is the proteins with high centrality in theY. pestishost–pathogen interactome that are most important for pathogen fitness during infection, and highlight the importance of pathogen proteins that likely cause significant perturbation of the host interactome.
Databáze: Directory of Open Access Journals