Images in Immunotherapy and Precision Oncology: Angiosarcoma of the Spleen and Liver

Autor:	Anagha Deshpande, Javier Munoz, Katalin Kelemen, Vrushali Dabak, Amr Hanbali, Razelle Kurzrock
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	splenic angiosarcoma hepatic angiosarcoma nivolumab ipilimumab Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Immunologic diseases. Allergy RC581-607
Zdroj:	Journal of Immunotherapy and Precision Oncology, Pp 56-58 (2023)
Druh dokumentu:	article
ISSN:	2666-2345 2590-017X
DOI:	10.36401/JIPO-22-22
Popis:	Primary splenic or hepatic angiosarcomas are ultra-rare and aggressive malignancies associated with poor prognosis. The mainstay treatments are surgical resection and chemotherapy. We report a case of angiosarcoma in a 50-year-old woman who presented with bruising, fatigue, ecchymosis, and hepatosplenomegaly. She was treated with the multi-kinase inhibitor sunitinib for 4 weeks before developing a splenic hemorrhage and succumbing. Recent studies have demonstrated the clinical benefit of immunotherapies in angiosarcomas. Additionally, sequencing techniques have showcased the diverse molecular aberrations involved in angiosarcomas, which offer opportunities for precision-matched targeted therapies such as inhibitors of the VEGF/VEGFR axis and PI3K/Akt/mTor pathway.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/8e06bad67679485d8fdfb563e1d7cf3c Zobrazit plný text záznamu View record in DOAJ