The aqueous extract of Artemisia Absinthium L. stimulates HO-1/MT-1/Cyp450 signaling pathway via oxidative stress regulation induced by aluminium oxide nanoparticles (α and γ) animal model
| Autor: | Esmaeil Karami, Zahra Goodarzi, Seyed Jamaleddin Shahtaheri, Mehrafarin Kiani, Mohammad Faridan, Mahmoud Ghazi-Khansari |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | BMC Complementary Medicine and Therapies, Vol 23, Iss 1, Pp 1-18 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2662-7671 03686825 |
| DOI: | 10.1186/s12906-023-04121-6 |
| Popis: | Abstract Background This research aimed to evaluate the protective effects of Artemisia Absinthium L. (Abs) against liver damage induced by aluminium oxide nanoparticles (Al2O3 NPs) in rats, including both structural and functional changes associated with hepatotoxicity. Methods Thirty-six rats were randomly divided into six groups (n = 6). The first group received no treatment. The second group was orally administered Abs at a dose of 200 mg/kg/b.w. The third and fifth groups were injected intraperitoneally with γ-Al2O3 NPs and α-Al2O3 NPs, respectively, at a dose of 30 mg/kg/b.w. The fourth and sixth groups were pre-treated with oral Abs at a dose of 200 mg/kg/b.w. along with intraperitoneal injection of γ-Al2O3 NPs and α-Al2O3 NPs, respectively, at a dose of 30 mg/kg/b.w. Results Treatment with γ-Al2O3 NPs resulted in a significant decrease (P |
| Databáze: | Directory of Open Access Journals |
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