A Kaposi’s sarcoma-associated herpes virus-encoded microRNA contributes to dilated cardiomyopathy

Autor: Yanru Zhao, Huaping Li, Hengzhi Du, Zhongwei Yin, Mengying He, Jiahui Fan, Xiang Nie, Yang Sun, Huiying Hou, Beibei Dai, Xudong Zhang, Yuanyuan Cai, Kunying Jin, Nan Ding, Zheng Wen, Jiang Chang, Chen Chen, Dao Wen Wang
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-12 (2023)
Druh dokumentu: article
ISSN: 2059-3635
DOI: 10.1038/s41392-023-01434-3
Popis: Abstract Dilated cardiomyopathy (DCM) is the leading cause of heart transplantation. By microRNA (miRNA) array, a Kaposi’s sarcoma-associated herpes virus (KSHV)-encoded miRNA, kshv-miR-K12-1-5p, was detected in patients with DCM. The KSHV DNA load and kshv-miR-K12-1-5p level in plasma from 696 patients with DCM were measured and these patients were followed-up. Increased KSHV seropositivity and quantitative titers were found in the patients with DCM compared with the non-DCM group (22.0% versus 9.1%, p
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