| Autor: |
Jef Serré, Carolien Mathyssen, Tom Tanjeko Ajime, Tobias Heigl, Lieve Verlinden, Karen Maes, Annemieke Verstuyf, Didier Cataldo, Jeroen Vanoirbeek, Bart Vanaudenaerde, Wim Janssens, Ghislaine Gayan-Ramirez |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Respiratory Research, Vol 23, Iss 1, Pp 1-12 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1465-993X |
| DOI: |
10.1186/s12931-022-01997-9 |
| Popis: |
Abstract Background Evidence supports a critical role of vitamin D status on exacerbation in chronic obstructive pulmonary disease, indicating the need to avoid vitamin D deficiency in these patients. However, oral vitamin D supplementation is limited by the potential risk for hypercalcemia. In this study, we investigated if local delivery of vitamin D to the lungs improves vitamin D-mediated anti-inflammatory action in response to acute inflammation without inducing hypercalcemia. Methods We studied vitamin D sufficient (VDS) or deficient (VDD) mice in whom 1α,25(OH)2D3 (0.2 μg/kg) or a vehicle followed by lipopolysaccharide (LPS 25 µg) were delivered to the lung as a micro-spray. Results Local 1α,25(OH)2D3 reduced LPS-induced inflammatory cells in bronchoalveolar lavage (BAL) in VDS (absolute number of cells: − 57% and neutrophils − 51% p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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