| Autor: |
Kerri Basile, Rebecca J. Rockett, Kenneth McPhie, Michael Fennell, Jessica Johnson-Mackinnon, Jessica E. Agius, Winkie Fong, Hossinur Rahman, Danny Ko, Linda Donavan, Linda Hueston, Connie Lam, Alicia Arnott, Sharon C.-A. Chen, Susan Maddocks, Matthew V. O’Sullivan, Dominic E. Dwyer, Vitali Sintchenko, Jen Kok |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Viruses, Vol 14, Iss 9, p 2023 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1999-4915 |
| DOI: |
10.3390/v14092023 |
| Popis: |
In late November 2021, the World Health Organization declared the SARS-CoV-2 lineage B.1.1.529 the fifth variant of concern, Omicron. This variant has acquired over 30 mutations in the spike protein (with 15 in the receptor-binding domain), raising concerns that Omicron could evade naturally acquired and vaccine-derived immunity. We utilized an authentic virus, multicycle neutralisation assay to demonstrate that sera collected one, three, and six months post-two doses of Pfizer-BioNTech BNT162b2 had a limited ability to neutralise SARS-CoV-2. However, four weeks after a third dose, neutralising antibody titres were boosted. Despite this increase, neutralising antibody titres were reduced fourfold for Omicron compared to lineage A.2.2 SARS-CoV-2. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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