A Prospective Cohort Study Analysing 3-Dimensional Conformal Radiotherapy and Salivary Glands Preserving Intensity Modulated Radiotherapy with/without Concomitant Cisplatin Chemotherapy in Head and Neck Malignancies

Autor: M Santosh Krishna, Bhaskar Vishwanathan, B Naveen, Geeta S Narayanan
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Clinical and Diagnostic Research, Vol 15, Iss 12, Pp 04-09 (2021)
Druh dokumentu: article
ISSN: 2249-782X
0973-709X
DOI: 10.7860/JCDR/2021/51787.15736
Popis: Introduction: Most common toxicity of radiotherapy in head and neck malignancy patients is xerostomia. Xerostomia can be prevented by using salivary gland sparing Intensity Modulated Radiation Therapy (IMRT) technique. Aim: To compare Dose Volume Histogram (DVH) of salivary glands in IMRT and 3-Dimensional Conformal Radiation Therapy (3DCRT) and evaluation of xerostomia, mucositis and dysphagia in both groups. Materials and Methods: The present study was a prospective cohort study in which 30 patients were selected. Patients of head and neck cancer reporting to Department of Radiation Oncology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, India were included. Duration of study was one year (January 2013 to December 2013). Fifteen patients treated with IMRT and 15 patients with 3DCRT to a dose of 60-70 Gy in 30-35 fractions, with or without concomitant cisplatin. The DVH of salivary glands and incidence of xerostomia, mucositis and dysphagia was compared in both the groups. Patients were assessed during the course of radiotherapy and three months postradiotherapy. Results: Mean dose to contralateral parotid was 19.48 Gy in IMRT when compared to 47.31 Gy in 3DCRT. Mean dose to contralateral submandibular was 44.06 Gy in IMRT when compared to 67.63 Gy in 3DCRT. At three, six and seven weeks there was a difference in number of patients having reduced severity of mucositis in IMRT when compared to 3DCRT. There was no significant difference in dysphagia between both groups at three, six and seven weeks and one month after the treatment. No significant difference in xerostomia between both the groups at seven week and one month after treatment. At three months after treatment the difference in xerostomia was significant between both groups (p
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