A temperature-dependent investigation of the impact of metal nanoparticles on the structural integrity of serum albumin

Autor: Ajamaluddin Malik, Abdulaziz Alamri, Javed Masood Khan, Nojood Altwaijry, Abir Alamro, Abdullah S. Alhomida, Hamza Odeibat, Mohammad Shamsul Ola
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of King Saud University: Science, Vol 36, Iss 9, Pp 103419- (2024)
Druh dokumentu: article
ISSN: 1018-3647
DOI: 10.1016/j.jksus.2024.103419
Popis: Nanoparticles (NPs) have distinct properties due to their small size and high surface area-to-volume ratio. These characteristics result in unique features not seen in bulk materials. Metals, semiconductors, and polymers are among the many varieties. Nanomaterials are used in various industries, including medical, electronics, and environmental cleanup. However, their potential environmental and health consequences must be carefully considered. Metal nanoparticles (MNPs) have received significant attention due to their outstanding physicochemical features and diverse applications in various sectors. MNPs are utilized in different fields, from electronics to health. Previously, the effect of various metal nanoparticles on the structure, stability, and functionality of metabolic enzymes was investigated. Copper (Cu) NPs were found to have significant negative impacts on these enzymes. The focus of the current investigation turned to serum albumin, a vital plasma protein containing oxidized cysteine residues. The findings demonstrated that NPs had a minor impact on the structure and stability of serum albumin, in contrast to the effects observed on reduced cysteine-containing enzymes.
Databáze: Directory of Open Access Journals