Influence of testing environment and loading rate on intervertebral disc compressive mechanics: An assessment of repeatability at three different laboratories

Autor: Nicolas Newell, David Rivera Tapia, Tamanna Rahman, Shiyin Lim, Grace D. O'Connell, Timothy P. Holsgrove
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: JOR Spine, Vol 3, Iss 3, Pp n/a-n/a (2020)
Druh dokumentu: article
ISSN: 2572-1143
DOI: 10.1002/jsp2.1110
Popis: Abstract In vitro mechanical testing of intervertebral discs is crucial for basic science and pre‐clinical testing. Generally, these tests aim to replicate in vivo conditions, but simplifications are necessary in specimen preparation and mechanical testing due to complexities in both structure and the loading conditions required to replicate in vivo conditions. There has been a growing interest in developing a consensus of testing protocols within the spine community to improve comparison of results between studies. The objective of this study was to perform axial compression experiments on bovine bone‐disc‐bone specimens at three institutions. No differences were observed between testing environment being air, with PBS soaked gauze, or a PBS bath (P > .206). A 100‐fold increase in loading rate resulted in a small (2%) but significant increase in compressive mechanics (P
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