Prognostic impact of pre-existing interstitial lung disease in non-HIV patients with Pneumocystis pneumonia
| Autor: | Shohei Hamada, Hidenori Ichiyasu, Megumi Inaba, Hiroshi Takahashi, Tomoki Sadamatsu, Kimitaka Akaike, Aiko Masunaga, Yasumasa Tashiro, Naomi Hirata, Takeshi Yoshinaga, Takuro Sakagami |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | ERJ Open Research, Vol 6, Iss 2 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2312-0541 23120541 |
| DOI: | 10.1183/23120541.00306-2019 |
| Popis: | Background The increasing incidence of life-threatening Pneumocystis pneumonia (PCP) in non-HIV immunocompromised patients is a global concern. Yet, no reports have examined the prognostic significance of pre-existing interstitial lung disease (ILD) in non-HIV PCP. Methods We retrospectively reviewed the medical records of non-HIV PCP patients with (ILD group) or without (non-ILD group) pre-existing ILD. The clinical features and outcomes of the ILD group were compared with those of the non-ILD group. Cox regression models were constructed to identify prognostic factors. Results 74 patients were enrolled in this study. The 90-day mortality was significantly higher in the ILD group than in the non-ILD group (62.5% versus 19.0%, p |
| Databáze: | Directory of Open Access Journals |
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