Transarterial chemoembolisation in intermediate-stage hepatocellular carcinoma. Survey on clinical practice in hospitals in the Madrid Region

Autor: Ana Matilla Peña, Óscar Núñez-Martínez, Antonio Díaz-Sánchez, Fernando Pons-Renedo, Mariano Gómez-Rubio, Benjamín Polo-Lorduy, José L. Lledó-Navarro, María Trapero-Marugán, José María Ladero-Quesada, Elvira Poves-Martínez, Alberto Ibáñez-Pinto, Ana María Martín-Algívez, Mar Lozano-Maya, Raquel González-Alonso, Belén Piqueras-Alcol, Leticia González-Moreno, Conrado Fernández-Rodríguez, Francisco Gea-Rodríguez
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Annals of Hepatology, Vol 14, Iss 2, Pp 207-217 (2015)
Druh dokumentu: article
ISSN: 1665-2681
DOI: 10.1016/S1665-2681(19)30783-5
Popis: Background. Transarterial chemoembolisation (TACE), having demonstrated survival benefits, is the treatment of choice in intermediate-stage hepatocellular carcinoma, although there is great heterogeneity in its clinical application.Material and methods. A survey was sent to the Madrid Regional hospitals to assess applicability, indications and treatment protocols. The assessment was made overall and according to the type of hospital (groups A vs. B and C).Results. Seventeen out of 22 hospitals responded (8/8 group A, 9/ 14 group B-C). All do/indicate transarterial chemoembolisation, 13/17 at their own facilities. Eight of the 17 hospitals have multidisciplinary groups (5/8 A, 3/9 B-C). Nine hospitals perform > 20 procedures/year (7 group A), and 6 from group B-C request/perform < 10/year. It is performed on an “on-demand” basis in 12/17. In 5 hospitals, all the procedures use drug-eluting beads loaded with doxorubicin. The average number of procedures per patient is 2. The mean time from diagnosis of hepatocellular carcinoma to transarterial chemoembolisation is ≤ 2 months in 16 hospitals. In 11/17 hospitals, response is assessed by computed tomography. Radiological response is measured without specific criteria in 12/17 and the other five hospitals (4 group A) assessed using standardised criteria.Conclusion. Uniformity among the Madrid Regional hospitals was found in the indication and treatment regimen. The use of DEB-TACE has become the preferred form of TACE in clinical practice. The differentiating factors for the more specialised hospitals are a larger volume of procedures, decision-making by multidisciplinary committees and assessment of radiological response more likely to be standardised.
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