Additive and Lithographic Manufacturing of Biomedical Scaffold Structures Using a Versatile Thiol-Ene Photocurable Resin

Autor: Michael Kainz, Stjepan Perak, Gerald Stubauer, Sonja Kopp, Sebastian Kauscheder, Julia Hemetzberger, Adrián Martínez Cendrero, Andrés Díaz Lantada, Disha Tupe, Zoltan Major, Dominik Hanetseder, Veronika Hruschka, Susanne Wolbank, Darja Marolt Presen, Michael Mühlberger, Elena Guillén
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Polymers, Vol 16, Iss 5, p 655 (2024)
Druh dokumentu: article
ISSN: 2073-4360
90273273
DOI: 10.3390/polym16050655
Popis: Additive and lithographic manufacturing technologies using photopolymerisation provide a powerful tool for fabricating multiscale structures, which is especially interesting for biomimetic scaffolds and biointerfaces. However, most resins are tailored to one particular fabrication technology, showing drawbacks for versatile use. Hence, we used a resin based on thiol-ene chemistry, leveraging its numerous advantages such as low oxygen inhibition, minimal shrinkage and high monomer conversion. The resin is tailored to applications in additive and lithographic technologies for future biofabrication where fast curing kinetics in the presence of oxygen are required, namely 3D inkjet printing, digital light processing and nanoimprint lithography. These technologies enable us to fabricate scaffolds over a span of six orders of magnitude with a maximum of 10 mm and a minimum of 150 nm in height, including bioinspired porous structures with controlled architecture, hole-patterned plates and micro/submicro patterned surfaces. Such versatile properties, combined with noncytotoxicity, degradability and the commercial availability of all the components render the resin as a prototyping material for tissue engineers.
Databáze: Directory of Open Access Journals
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