| Autor: |
Wael Abu Dayyih, Raghad Layth, Mohammad Hailat, Bayan Alkhawaja, Lina Al Tamimi, Zainab Zakaraya, Aseel Aburumman, Nisreen Al Dmour, Mohamed J. Saadh, Hisham Al-Matubsi, Saed M. Aldalaen |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 13, Iss 1, Pp 1-5 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-023-28074-5 |
| Popis: |
Abstract Twelve healthy eight-week-old male Wistar rats weighing 200 g were used. Rats were chosen randomly, and their tails were identified and separated into cages/groups. The first group received an oral dose of 11.5 mg of levetiracetam in 5 mL of water, and the second group was given date syrup (250 g mixed with 250 mL water) for seven days, then 11.5 mg LEV in 5 mL water on day 7. One week of preadministered date molasses significantly decreased levetiracetam pharmacokinetic parameters in rats, such as Cmax (72 vs. 14 ng/mL, p = 0.01), Tmax (1.78 vs. 0.44 h, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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