Mechanisms of abemaciclib, a CDK4/6 inhibitor, induced apoptotic cell death in prostate cancer cells in vitro

Autor:	Gamze Guney Eskiler, Asuman Deveci Ozkan, Ayten Haciefendi, Cemil Bilir
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Abemaciclib Prostate cancer Apoptosis CDK4/6 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Translational Oncology, Vol 15, Iss 1, Pp 101243- (2022)
Druh dokumentu:	article
ISSN:	1936-5233
DOI:	10.1016/j.tranon.2021.101243
Popis:	The therapeutic effects of abemaciclib (ABE), an inhibitor of cyclin- dependent kinases (CDK) 4/6, on the proliferation of two types of prostate cancer (PC) cells were revealed. In this study, in vitro cytotoxic and apoptotic effects of ABE on metastatic castration-resistant prostate cancer (mCRPC) androgen receptor (AR) negative PC-3 and AR mutant LNCaP PC cells were analyzed with WST-1, Annexin V, cell cycle, reactive oxygen species (ROS), mitochondrial membrane potential, RT-PCR, western blot, and apoptosis protein array. ABE considerably inhibited the growth of PC cells in a dose-dependent manner (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/8da482e5e9ad4d8193a50b849235c240 Zobrazit plný text záznamu View record in DOAJ